Fig. 4. Manhattan plots of GWAS and MTAG results.

(a) DEP, (b) NEUR, (c) SWB. The left and right plots display the GWAS and MTAG results, respectively, for a fixed set of SNPs. The x-axis is chromosomal position, and the y-axis is the significance on a − ${\text{log}}_{10}$scale. The upper dashed line marks the threshold for genome-wide significance ( $P=5\times {10}^{-8}$), and the lower line marks the threshold for nominal significance ( $P={10}^{-5}$). Each approximately independent genome-wide significant association (“lead SNP”) is marked by ×. The mean ${\chi }^2$-statistic across all SNPs included in the analysis is displayed in the top left corner of each plot.