Skip to main content
. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Nat Genet. 2018 Jan 1;50(2):229–237. doi: 10.1038/s41588-017-0009-4

Fig. 5. Regression-based test of replicability of MTAG-identified loci.

Fig. 5

For each trait and in each of two independent replication cohorts (HRS and Add Health, combined N = 12,641), we regressed the estimated effect sizes of the MTAG-identified loci on their winner’s-curse-adjusted MTAG effect sizes. The intercept is constrained to zero in these regressions. The plotted regression coefficients are the sample-size-weighted means across the replication cohorts, with 95% intervals. See Supplementary Note for details and cohort-level results.