. Author manuscript; available in PMC: 2018 Jul 22.
Published in final edited form as: Nat Genet. 2018 Jan 22;50(2):270–277. doi: 10.1038/s41588-017-0036-1
Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms