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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Int J Cancer. 2017 Dec 1;142(7):1467–1479. doi: 10.1002/ijc.31166

Figure 4.

Figure 4

Effect of N-9 and ι-carrageenan on Ad vector type 26 and 35 transduction of the cervicovaginal mucosa. Depoprovera-treated mice (n=5/group) were inoculated Ivag with or without N-9 followed 5 hours later with Ad vectors (2.5 × 109 vp) given in CMC or i-carrageenan. Longitudinal in vivo bioluminescence imaging of the genital region of mice inoculated Ivag of with Ad26 (A) and Ad35 (B) vectors expressing firefly luciferase. Data are expressed as mean +/− SEM (A–B). For each time point (18hrs), 20ul of of 15mg/ml D-luciferin was instilled Ivag 3min prior to imaging. Confocal microscopy imaging of GFP expression in the cervicovaginal mucosa epithelium after Ivag instillation of Ad26 (C) and A35 (D) vectors expressing GFP. One-way analysis of variance and multiple comparisons (Kruskal-Wallis H test) was performed to determine statistical significance.