Skip to main content
. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Mol Cancer Res. 2017 Nov 29;16(2):256–268. doi: 10.1158/1541-7786.MCR-17-0304

Fig. 7. ZER reduces HCC tumor growth and lung metastasis.

Fig. 7

(A) NSG mice bearing subcutaneous Huh7 xenografts were injected (I.P.) with ZER (20 mg/kg/day) or vehicle for 3 weeks. Tumor volume during treatment, representative pictures of tumors and average tumor weights at the end of experiment are provided. (B) NSG mice bearing orthotopic MHCC-LM3 xenografts were treated with ZER for 3 weeks. Representative pictures of the tumors and ratio of tumor weight to liver weight of mice are shown. (C) Ki-67- and (D) AFP- stained tumor sections in vehicle (HPBCD) or ZER treated mice. The numbers of Ki-67 positive cells at 20X magnification are provided within each picture. (E) Metastatic lung tumors developed in NSG mice bearing orthotopic MHCC-LM3 xenografts treated with vehicle or ZER for 3 weeks, and (F) H&E stained lung sections showing metastatic nodules.