Table 4.
HLA Allele Remapping for WS Database LiftOver and Consensus Linking Functions
| Reference Database Release in which the change occurred |
Rationale | Original Allele Name | Original Accession Number |
Current Allele Name | Current Accession Number |
Current Allele Present in Version 3.25.0? |
Accession Number Change? |
WS Database Action When Original Allele Name Has Been Submitted |
|---|---|---|---|---|---|---|---|---|
| 3.17.0 | Sequence identical | B*49:15 | HLA05834 | B*49:01:01 | HLA00340 | YES | YES | Use 3.25.0 version of Current Allele Name |
| 3.20.0 | Sequence renamed | A*26:03:02 | HLA04741 | A*26:111 | HLA04741 | YES | NO | |
| 3.21.0 | Sequence error | DRB1*11:11:02 | HLA02157 | DRB1*11:11:01 | HLA00765 | YES | YES | |
| 3.22.0 | Sequence error | A*03:194 | HLA11939 | A*03:213 | HLA12966 | YES | YES | |
| 3.24.0 | Sequence error | A*23:69 | HLA12676 | A*23:01:01:01 | HLA00048 | YES1 | YES | |
| Sequence identical | DRB1*08:01:03 | HLA02257 | DRB1*08:01:01 | HLA00723 | YES | YES | ||
| 3.25.0 | Sequence renamed | DRB1*04:94:02N | HLA14178 | DRB1*04:212N | HLA14178 | YES | NO | |
| 3.26.0 | Sequence renamed | A*30:02:12 | HLA09547 | A*30:100 | HLA14873 | YES | YES | Use 3.25.0 version of Original Allele Name |
| Sequence error | C*17:01:01:01 | HLA00481 | C*17:01:01:02 | HLA04311 | YES | YES | ||
| 3.27.0 | Sequence renamed | DPB1*35:01:02 | HLA04110 | DPB1*621:01 | HLA04110 | NO2 | NO | |
| Sequence identical | DQB1*06:220 | NA3 | DQB1*06:217 | HLA16016 | NO2 | NA3 | Change to DQB1*06:01:014 | |
| 3.28.0 | Sequence identical | DPA1*02:02:01 | HLA00508 | DPA1*02:07:01:01 | HLA15619 | NO5 | YES | Use 3.25.0 version of Original Allele Name |
| 3.29.0 | Sequence identical | DQB1*03:01:01:13 | HLA07476 | DQB1*03:01:01:07 | HLA17167 | NO6 | YES | Change to DQB1*03:01:01:017 |
Changes to HLA allele names and their associated accession numbers that occurred in Reference Database versions 3.15.0 – 3.29.0, and the action taken by the WS Database when the original allele name is encountered are shown. The data in all but the last column are derived from the hla_nom.txt and allelelist_history.txt files in Reference Database version 3.28.0.
NA: Not applicable.
The allele name in Reference Database version 3.25.0 is A*23:01:01.
This current allele name was assigned in Reference Database version 3.27.0.
No accession number was released for the DQB1*06:220 allele; this allele name has not appeared in any release version.
DQB1*06:01:01 is the lowest numbered allele sharing a common prefix (DQB1*06) with DQB1*06:220 (or DQB1*06:217).
This current allele name was assigned in Reference Database version 3.28.0.
Both the original and current allele names were assigned in Reference Database version 3.29.0.
DQB1*03:01:01:01 is the lowest numbered allele sharing a common prefix (DQB1*03:01:01) with DQB1*03:01:01:13 (or DQB1*03:01:01:07)