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. 2018 Feb 8;8:2624. doi: 10.1038/s41598-018-21084-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro triggered release study. (A) Shows the US-trigger intensity profile and the concentration of released paclitaxel in sink solution; (B) Shows the cumulative release plot, for both with US-trigger. (C) Shows the TEM images of PSPLBC before and after US-trigger. The observed lipid fragments confirmed the complete destruction of intact PSPLBC into lipid fragments upon US exposure. (D) Ultrasonography of B and PSPLBC in both B-mode (grey) and contrast mode (Solaris) using 5–7 MHz probe.