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. 2018 Feb 8;8:2624. doi: 10.1038/s41598-018-21084-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cellular internalization study. (A) CLSM images of MDA-MB-231 and B16F10 cells treated with free rhodamine-6G dye, free dye+US, rhodamine-6G loaded PSPLBC, and rhodamine-6G loaded PSPLBC+US. The fluorescence intensity was quantified from three random CLSM images. (*p ≤ 0.05). (B) Mechanism of PSPLBC cellular internalization studied using cells pre-treated with various metabolic & endocytic inhibitors. CLSM images show the uptake of PSPLBC by pretreated cells, both with and without application of trigger. (C) Cryo-FEG-SEM images of the cell without US-treatment and immediately after PSPLBC+US treatment. The red arrows show the sonopores on the cell surface, the inset shows the zoom-in picture of a sonopore, (scale bar = 1 µm).