Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 8;9:577. doi: 10.1038/s41467-018-03025-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — A specific methylation signature at keratin gene clusters identifies two distinct subclasses of AK/cSCC. a UCSC genome browser tracks showing significant DNA methylation differences (Δβ, P < 0.05, F-test, vertical green lines) at the keratin gene cluster on chromosome 12 for AK (upper part) and cSCC (lower part) in comparison to healthy epidermis. b Specific DNA methylation patterns of the genes encoding keratins K5, K14, K15, and K80 (KRT5, KRT14, KRT15, and KRT80, respectively). Heatmaps show DNA methylation levels (in β values, from blue (= 0) to red (= 1)) of probes (columns) located in the promoter and gene body, for individual healthy, AK, and cSCC samples (rows). Filled and empty circles denote the two distinct subclasses of AK (purple) and cSCC (black), respectively. c Principal component analysis of healthy, AK, and cSCC epidermis samples based on 1364 keratin-associated methylation probes. For comparisons, keratin methylation patterns from 26 additional tumor entities were also included. d Hierarchical clustering of the dataset shown in c. The 26 tumor entities depicted in this graph, and also used in c, are from left to right: testicular germ cell tumors, liver hepatocellular carcinoma, esophageal carcinoma, head and neck squamous cell carcinoma, lung squamous carcinoma, cervical squamous cell carcinoma and endocervical adenocarcinoma, uterine corpus endometrial carcinoma, uterine carcinosarcoma, lung adenocarcinoma, stomach adenocarcinoma, ovarian serous cystadenocarcinoma, bladder urothelial carcinoma, colon adenocarcinoma, rectum adenocarcinoma, skin cutaneous melanoma, adrenocortical carcinoma, glioblastoma multiforme, sarcoma, thyroid carcinoma, kidney renal papillary cell carcinoma, cholangiocarcinoma, prostate adenocarcinoma, breast invasive carcinoma, pancreatic adenocarcinoma, kidney renal clear cell carcinoma, and mesothelioma