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. 2018 Feb 8;8:2628. doi: 10.1038/s41598-018-20518-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proteome of Csde1 deletion mutants. Total MEL cell lysates of 2 Hm clones (H1, H2), 2 Del clones (D1, D2), 2 clones with a heterozygous out-of-frame deletion (C1, C2), and the parental MEL cells (wt) were analysed by mass spectrometry. Three lysates were analysed for each clone. Data were analysed by MaxQuant and Perseus (A) Proteins differentially regulated between Hm and control clones (C1, C2 and wt), or between Del and control clones were subjected to Pearson clustering. (blue: upregulated, yellow: downregulated, grey: not detected). Proteins and their Z-score in the order of this heatmap are listed in Supplementary Table S-V. (B) The overlap between genes encoding proteins differentially expressed between Del and control clones (169, green circle); between Hm and control genes (968, blue circle) and genes encoding Csde1-bound transcripts of which proteins were detected by mass spectrometry (222, red circle) (FDR < 0.05).