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. 2018 Feb 8;8:2673. doi: 10.1038/s41598-018-20788-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fitting a mathematical model of prostate cancer to PSA values. Predictions of PSA follow the fitting period of the first 2 and half cycles of intermittent androgen suppression. Dash-dotted lines represent 10%, 50%, and 90% points of bootstrap samples for each time point. Crosses show actual measurements of PSA. The darkness shows the density of bootstrapped solutions.