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. 2018 Feb 8;8:2673. doi: 10.1038/s41598-018-20788-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time vs probability that the maximum PSA among 100 bootstrap samples is less than 100 ng/ml. The length of the time period that the maximal PSA value among 100 bootstrap samples is less than 100 ng/ml after the first 2 and half cycles was estimated. If patients were classified off-study before the first 2 and half cycles, then the time from the off study was estimated. Panel (a) is for type (i) patients, panel (b) is for type (ii) patients, and panel (c) is for type (iii) patients. In each panel, the solid line corresponds to the optimized IAS, the dash-dotted line corresponds to the conventional IAS, and the dotted line corresponds to CAS. In the conventional IAS, the hormone therapy is stopped when the PSA level is less than 0.1 ng/ml 40 weeks after the restart of the hormone therapy and the hormone therapy is resumed when the PSA level becomes greater than or equal to 1 ng/ml.