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. 2018 Feb 8;9:583. doi: 10.1038/s41467-018-02890-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Decreased RFX1 and increased IL-17A expression in CD4⁺ T cells of SLE patients. mRNA (a) and protein (b) expression levels of RFX1 in CD4⁺ T cells of inactive SLE patients (n = 8), active SLE patients (n = 23 for mRNA and n = 15 for protein) and healthy subjects (n = 14 for mRNA and n = 9 for protein). Representative results of western blot analysis are shown in (c). IL-17A mRNA expression level in CD4⁺ T cells (d) and protein level in serum (e) of inactive and active SLE patients and healthy subjects. f Correlation between RFX1 and IL-17A at the mRNA level. g Correlation between RFX1 protein levels in CD4⁺ T cells and IL-17A protein levels in serum. h and i mRNA expression levels of IL-17F and RORC in CD4⁺ T cells of inactive SLE patients (n = 8), active SLE patients (n = 15) and healthy subjects (n = 9). Small horizontal lines indicate the mean (±s.e.m) in a, b, d, e, h, i. *P < 0.05; **P < 0.01; n.s., not significant, compared between the indicated groups. Student’s t-test (two-tailed) and Mann–Whitney U-test (two-tailed) were used to compare the results. Sperman’s correlation coefficient was used for the correlation analysis (two-tailed)