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. 2018 Feb 8;8:2630. doi: 10.1038/s41598-018-20815-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of CB and AF405 uptake in A431-OATP cells. Transport of CB (2 µM for OATP1B1 and 10 µM for OATP2B1) and AF405 (5 µM, OATP1B3) was measured for 30 minutes in the absence or presence of the investigated compounds. Transport was determined by subtracting fluorescence in A431-mock cells. Transport measured in cells with the dye alone was set to 100% and the effect of the compounds was compared to this value. Experiments were performed in triplicates with three parallels in each biological replicate. Average ± SD values are shown.