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. 2018 Feb 8;8:2608. doi: 10.1038/s41598-018-20708-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time course of the incorporation and the stability of compound 1b in the plasma membrane. FTR-cells expressing the iodide-sensitive YFP protein were incubated in phosphate-buffered solution containing 137 mM NaCl. Iodide influx was estimated by the YFP fluorescence quenching upon addition of ICl to a final concentration of 100 mM. (a) Kinetics of the incorporation of compound 1b in the plasma membrane. The activity of the compound (at 12 µM concentration) was measured, as maximum quenching rate, as function of time. (b) Stability of compound 1b in the plasma membrane. After 45 min incubation with 12 µM 1b, cells were washed twice and the residual transport activity measured during 60 minutes. Symbols are means of 3 different experiments and vertical bars are standard error of the mean.