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. 2018 Feb 8;8:2675. doi: 10.1038/s41598-018-20855-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Accuracy of multi-marker models in the diagnosis of TB disease. Receiver operator characteristics (ROC) curve showing the accuracy of the most accurate four-marker biosignature (IFN-γ_nil + TGF-α_nil + IL-1ra_Ag-nil + MIP-1β_Ag-nil) in the diagnosis of TB disease regardless of HIV infection status when all host markers evaluated were considered (251 study participants) (A), frequency of analytes in the top 20 general discriminant analysis (GDA) models that most accurately classified study participants as TB disease or ORD irrespective of HIV status when all host markers evaluated were considered (B), ROC curve showing the accuracy of the most accurate five-marker biosignature (IFN-γ_nil + MIP-1β_nil + TGF-α_nil + TGF-α_Ag-nil + VEGF_Ag-nil) in the diagnosis of TB disease regardless of HIV status when analysis was done only on the host markers that were evaluated on all study participants (i.e., excluding IL-1ra, IFN-α2 and TNF-α) (C), and frequency of analytes in the top 20 GDA models that most accurately diagnosed TB disease regardless of HIV status when analysis was done only on the host markers that were evaluated on all study participants (D). The bar graphs (B,D) indicate the frequency of analytes in the most accurate GDA models.