Table 2.
Median levels of individual analytes (pg/ml) in TB patients (n = 179) and individuals with ORD (n = 274) and accuracies in the diagnosis of TB disease.
| Analyte | TB (IQR) | ORD (IQR) | P-value | AUC (95% CI) | Cut-off | Sens (95% CI) | Spec (95% CI) |
|---|---|---|---|---|---|---|---|
| IL-1raAg-N | 124.1(26.4–486) | 78.7(0–361.1) | 0.032 | 0.58 (0.51–0.65) | >90.3 | 0.60 (0.50–0.69) | 0.52(0.43–0.60) |
| VEGFN | 102.2(0.0–213) | 40.7(0.0–118.5) | <0.001 | 0.63(0.58–0.68) | >74.8 | 0.60 (0.53–0.68) | 0.60(0.54–0.65) |
| IFN-γN | 17.6(7.7–36) | 5.6(1.1–14.0) | <0.001 | 0.72(0.67–0.77) | >8.7 | 0.73(0.66–0.78) | 0.63(0.57–0.68) |
| IFN-γAg-N | 115.8(21.5–340) | 23.1(0.8–169.3) | <0.001 | 0.64(0.59–0.69) | >46.5 | 0.67 (0.60–0.74) | 0.60 (0.54–0.66) |
| IFN-α2N | 35.9(14.6–55) | 20.0(7.7–39.6) | 0.001 | 0.62(0.55–0.69) | >24.9 | 0.62(0.52–0.71) | 0.58(0.49–0.66) |
| sCD40LN | 2322.8(1197.4–4507) | 1344.4(765.6–2611.2) | <0.01 | 0.63(0.58–0.69) | >1717 | 0.63(0.55–0.70) | 0.60(0.54–0.66) |
| MIP-1βN | 752.6(386.8–1673) | 1289.1(651.2–2466.0) | <0.01 | 0.63(0.58–0.68) | <1164 | 0.62(0.54–0.69) | 0.54 (0.49–0.61) |
| MIP-1βA-N | 467.5(19.6–1160) | 627.9(22.6–2013.8) | 0.05 | 0.55(0.50–0.60) | <705.6 | 0.63(0.55–0.69) | 0.49(0.43–0.55) |
| IL-1αN | 9.1(0.5–29) | 14.2(3.1–52.5) | 0.017 | 0.50(0.45–0.56) | <4.8 | 0.55(0.47–0.62) | 0.51(0.44–0.56) |
| TGF-αN | 18.0(11.2–30) | 9.8(4.2–19.1) | <0.001 | 0.68(0.63–0.73) | >12.9 | 0.71(0.64–0.78) | 0.60(0.54–0.66) |
| TGF-αA-N | 0.9(−1.8–6.0) | 0.0(−1.8–2.9) | 0.021 | 0.56(0.51–0.62) | >0.6 | 0.53(0.456–0.60) | 0.60(0.54–0.66) |
| MMP-9N | 809798.8(455045.7–1275200) | 508208.0(298946.4–865698.0) | <0.001 | 0.66(0.60–0.71) | >618289 | 0.60(0.52–0.68) | 0.61(0.55–0.67) |
| MMP-9Ag-N | 36703.4(−40408–234300) | 4119.5(−82800–113700) | 0.005 | 0.58(0.52–0.64 | >3578 | 0.59(0.50–0.67) | 0.50(0.44–0.56) |
Only analytes with p-values < 0.05 in the Mann Whitney U test are shown. IQR = Inter-quartile range, AUC = area under the ROC curve, Sens = sensitivity, spec = specificity N = Unistimulated levels, Ag-N = antigen specific levels.