Table 4.
Performance of host biosignatures in smear positive and smear negative TB patients regardless of HIV infection status.
| Biosignature | Accuracy measure | Accuracy in smear Positive TB patients | Accuracy in Smear Negative TB Patients | ||
|---|---|---|---|---|---|
| Training set | Test set | Training set | Test set | ||
| Biosignature (i) | AUC | 0.82 (0.75–0.90) | 0.70 (0.61–0.79) | ||
| IFN-γN, TGF-αN, IL-1RaAg-N, MIP-1βAg-N | Sensitivity | 72.3% (34/47) | 80.0% (16/20) | 60% (24/40) | 57.5% (23/40) |
| Specificity | 85.1% (86/101) | 79.5% (35/44) | 73.1% (106/145) | 71.0% (103/145) | |
| Biosignature (ii) | AUC | 0.82 (0.77–0.88) | 0.70 (0.60–0.79) | ||
| IFN-γN, MIP-1βN, TGF-αN, TGF-αAg-N, VEGFAg-N | Sensitivity | 71.8% (61/85) | 56.8% (21/37) | 57.8% (26/45) | 55.6% (25/45) |
| Specificity | 83.7% (128/153) | 90.8% (59/65) | 75.2% (164/218) | 72.9% (159/218) | |
| Biosignature (iii) | AUC | 0.81 (0.73–0.90) | 0.74 (0.63–0.84) | ||
| IFN-γN, IFN-αN, sCD40LN, IL-1αN, MMP-2N, MMP-9N, IFN-α2Ag-N | Sensitivity | 73.9% (34/46) | 75.0% (15/20) | 65% (26/40) | 60% (24/40) |
| Specificity | 82.2% (83/101) | 90.7% (39/43) | 72.9% (105/144) | 70.8% (102/144) | |
| Biosignature (iv) | AUC | 0.83 (0.77–0.88) | 0.70 (0.60–0.79) | ||
| IFN-γN, TGF-αN, IL-1αN, MMP-2N, EGFAg-N, VEGFAg-N, TGF-α Ag-N | Sensitivity | 70.6% (60/85) | 75.7% (28/37) | 57.8% (26/45) | 55.6% (25/45) |
| Specificity | 85.0% (130/153) | 80.0% (52/65) | 75.2% (164/218) | 72.9% (159/218) | |
Cut-off values for determination of sensitivity and specificity were selected based on the Younden’s Index.