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. 2018 Feb 8;8:2612. doi: 10.1038/s41598-018-21000-0

Figure 2.

Figure 2

Analysis of the six alpha chains of type IV collagen in the basement membrane of keratinized and non-keratinized mucosa. IHC staining for α1(IV) (A,B), α2(IV) (C,D), α3(IV) (E,F), α4(IV) (G,H), α5(IV) (I,J), α6(IV) (K,L) was performed to compare the expression of these proteins in keratinized (A,C,E,G,I,K) and non-keratinized mucosa (B,D,F,H,J,L). Nuclei were counterstained with DAPI (blue). Yellow arrows indicate positive signals for each antibody in the basement membrane. Note that α5(IV) and α6(IV) chains are highly expressed in keratinized mucosa. Results are representative of at least three independent experiments. E, epithelial tissue; M, Mesenchymal tissue.