Fig. 2.

Results of the F test to test the age-by-group interaction term to predict volume change. (A) Clusters in the images represent voxels in which there is a significant difference in the relationship between age and atrophy rate across the 3 groups. (B) Graphs explain these relationships; summary slopes of voxel change for each individual at the voxel of interest are plotted against baseline age in controls, MCI, and AD patients. Positive values of change in voxel volume indicate expansion, and negative values represent voxel contraction. Results are adjusted for APOE genotype and white-matter hyperintensity volume. Each voxel of interest is located within an FWE corrected p < 0.05 cluster indicated by the crosshairs in the images. Abbreviations: AD, Alzheimer's disease; MCI, mild cognitive impairment.