Table 1.
Included studies and participants by region, sex, HIV status, and anal diagnosis
| Number of studies (n=95)* | Normal diagnosis (n=8534) | Low grade diagnosis†(n=5730) | High grade diagnosis‡(n=2024) | Cancer (n=2358) | Total (n=18 646) | |||
|---|---|---|---|---|---|---|---|---|
| Region | ||||||||
| North America | 29 (31%) | 3242 (38%) | 2313 (40%) | 767 (38%) | 663 (28%) | 6985 (37%) | ||
| Europe | 44 (46%) | 2301 (27%) | 2056 (36%) | 586 (29%) | 1324 (56%) | 6267 (34%) | ||
| Latin America | 11 (12%) | 1790 (21%) | 674 (12%) | 320 (16%) | 225 (10%) | 3009 (16%) | ||
| Asia and Oceania | 13 (14%) | 1150 (13%) | 562 (10%) | 332 (16%) | 123 (5%) | 2167 (12%) | ||
| Africa | 3 (3%) | 51 (1%) | 125 (2%) | 19 (1%) | 23 (1%) | 218 (1%) | ||
| Sex and HIV status | ||||||||
| Men | 79 (83%) | 5446 (64%) | 4763 (83%) | 1599 (79%) | 1042 (44%) | 12 850 (69%) | ||
| HIV negative | 29 (31%) | 1695 (20%) | 902 (16%) | 339 (17%) | 144 (6%) | 3080 (17%) | ||
| Known MSM | 17 (18%) | 1565 (18%) | 843 (15%) | 310 (15%) | 1 (<1%) | 2719 (15%) | ||
| HIV unknown | 18 (19%) | ·· | ·· | ·· | 759 (32%) | 759 (4%) | ||
| Known MSM | 0 | ·· | ·· | ·· | 0 | 0 | ||
| HIV positive | 59 (62%) | 3751 (44%) | 3861 (67%) | 1260 (62%) | 139 (6%) | 9011 (48%) | ||
| Known MSM | 42 (44%) | 3202 (38%) | 3474 (61%) | 1114 (55%) | 17 (1%) | 7807 (42%) | ||
| Women | 55 (58%) | 3088 (36%) | 967 (17%) | 425 (21%) | 1316 (56%) | 5796 (31%) | ||
| HIV negative | 29 (31%) | 1764 (21%) | 323 (6%) | 194 (10%) | 226 (10%) | 2507 (13%) | ||
| HIV unknown | 19 (20%) | ·· | ·· | ·· | 1077 (46%) | 1077 (6%) | ||
| HIV positive | 23 (24%) | 1324 (16%) | 644 (11%) | 231 (11%) | 13 (1%) | 2212 (12%) | ||
MSM=men who have sex with men.
*
Individual categories sum to more than the total due to some studies including patients from more than one region, gender, or HIV status.
†
Low-grade diagnosis is defined as atypical squamous cells of undetermined significance, low-grade squamous intraepithelial lesion, or anal intraepithelial neoplasia grade 1.
‡
High-grade diagnosis is defined as high-grade squamous intraepithelial lesion, atypical squamous cells but cannot exclude high-grade squamous intraepithelial lesion, or anal intraepithelial neoplasia grade 2 or 3.