Table 2.

Number and prevalence of single and multiple infections of HPV types in HPV-positive anal cancer by HIV status

	HIV-negative/unknown*			HIV-positive
	Overall prevalence	Single	Multiple	Overall prevalence	Single	Multiple
HPV16	1333/1554 (86%)	1216 (78%)	117 (8%)	96/144 (67%)	63 (44%)	33 (23%)
HPV18	66/1554 (4%)	37 (2%)	29 (2%)	21/144 (15%)	3 (2%)	18 (13%)
HPV33	44/1369 (3%)	32 (2%)	12 (1%)	12/130 (9%)	3 (2%)	9 (7%)
HPV6	54/1415 (4%)	29 (2%)	25 (2%)	8/124 (6%)	3 (2%)	5 (4%)
HPV58	23/1198 (2%)	18 (2%)	5 (<1%)	1/123 (1%)	0	1 (1%)
HPV35	12/1332 (1%)	11 (1%)	1 (<1%)	0/123	0	0
HPV31	19/1338 (1%)	11 (1%)	8 (1%)	6/129 (5%)	2 (2%)	4 (3%)
HPV52	21/1198 (2%)	9 (1%)	12 (1%)	12/123 (10%)	2 (2%)	10 (8%)
HPV11	37/1415 (3%)	10 (1%)	27 (2%)	10/124 (8%)	1 (1%)	9 (7%)
HPV45	10/1329 (1%)	6 (1%)	4 (<1%)	8/125 (6%)	3 (2%)	5 (4%)
HPV56	6/1190 (1%)	4 (<1%)	2 (<1%)	1/123 (1%)	0	1 (1%)
HPV39	7/1190 (1%)	2 (<1%)	5 (<1%)	8/123 (7%)	1 (1%)	7 (6%)
HPV68	4/1190 (<1%)	2 (<1%)	2 (<1%)	10/123 (8%)	0	10 (8%)
HPV59	2/1190 (<1%)	1 (<1%)	1 (<1%)	5/123 (4%)	0	5 (4%)
HPV51	11/1190 (1%)	0	11 (1%)	8/123 (7%)	1 (1%)	7 (6%)
Any HPV	1424/1430 (>99%)	1279 (89%)	145 (10%)	128/130 (98%)	74 (57%)	54 (42%)
HPV16/18	552/629 (88%)	499 (79%)†	53 (8%)‡	87/118 (74%)	58 (49%)†	29 (25%)‡
HPV6/11/16/18	579/629 (92%)	541 (86%)†	38 (6%)‡	91/118 (77%)	66 (56%)†	25 (21%)‡
HPV6/11/16/18/31/33/45/52/58	618/629 (98%)	599 (95%)†	19 (3%)‡	109/118 (92%)	89 (75%)†	20 (17%)‡

Data are n/N (%) for overall prevalence. HPV=human papillomavirus.

^*See appendix p 12 for sensitivity analyses showing known HIV-negative and HIV unknown anal cancers separately.

^†Single infections were those in the absence of other HPV types.

^‡Multiple infections were in the presence of other known HPV types.