Table 1.
Summary of review contents. This review covers diverse but connected (figure 1) aspects of energy homeostasis. This table is intended to serve as a quick overview and guide to the phenomena and models we discuss.
physiological problem | methods | data sources | section | electronic supplementary material sections |
---|---|---|---|---|
Endocrine mechanisms (§2) | ||||
endocrine regulation of blood glucose | differential equations | plasma metabolite and hormone concentrations | 2.1 | (S2.1–S2.4) |
blood glucose dynamics after eating | differential equations | stomach fullness and circulating metabolites | 2.1 | (S2.5–S2.7) |
inter-individual variation in glucostasis | machine learning | patient-specific behavioural data (e.g. sleep duration), metabolites | 2.2 | (S2.8–S2.10), box 1 |
emergence of diabetes and leptin resistance | multiscale modelling | circulating metabolites, pancreatic β cell mass | 2.3 | (S2.11–S2.14) |
Body composition (§3) | ||||
changes in body weight and composition | differential equations | average food intake, body weight and composition | 3.1 | (S3.1–S3.7), box 2 |
effect of macronutrient intake on growth and development | differential equations | growth curves, body composition measurements, energy intake/expenditure | 3.2 | (S3.8) |
Feeding behaviour (§4) | ||||
food intake within a meal | control theory | feeding time series | 4.1 | (S4.1) |
endocrine regulation of food intake | differential equations | food intake, circulating hormone concentrations | 4.1 | (S4.2, S4.3) |
food intake planning | control theory | feeding time series | 4.1 | (S4.5, S4.6) |
learning the rules governing behaviour | machine learning | feeding time series, neuronal activity | 4.2 | (S4.7, S4.8) |