Figure 1.

(a) Schematic view of the NFκB regulatory cycle showing the key steps of IκB production, NFκB nuclear translocation and sequestration of NκB IκB. (b) Two distinct mechanisms of interaction of NFκB with the genomic sites: passive binding/unbinding and molecular stripping. (c) Distribution of unbinding rates, k_doff of NFκB from DNA-binding sites inferred from PBMs experiments [10]. (d) Shown are stochastic trajectories of 100 genomic sites of NFκB sampled from the histogram distribution in c. (Online version in colour.)