Figure 1.

Overexpression of syndecan-2 increases survival in transgenic (TG) mice 24 weeks after radiation exposure. C57BL/6 wild-type (WT; n = 10) and scavenger receptor A enhancer/promoter–human syndecan-2 (hsdc2) TG mice (n = 10) with macrophage-specific overexpression of hsdc2 were exposed to a single dose of 14 Gy radiation delivered to the thorax by a Philips RT 250 X-ray therapy unit at 8–11 weeks of age. Survival was 100% in TG mice at Day 168 (Week 24) compared with 40% in irradiated WT (WT Rad) mice (P < 0.001). Survival for WT versus TG mice (P < 0.001); data are presented as a Kaplan–Meier survival curve.