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Model illustrating how G-MDSC trafficking contributes to PH through CXCR2. (1) Induction of bone marrow (BM) proliferation and release of G-MDSCs into circulation. (2) G-MDSC–expressed CXCR2 binds vascular endothelium–derived ligand, CXCL1 (human homolog, CXCL8), leading to (3) G-MDSC adhesion, diapedesis, and (4) Arg1- and iNOS-mediated lung vascular remodeling and PH.
