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. 2018 Mar 1;28(7):507–520. doi: 10.1089/ars.2016.6911

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© Marrit Putker, et al., 2018; Published by Mary Ann Liebert, Inc.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 4. — PPP inhibition reversibly dampens circadian rhythms in mouse fibroblasts. Effect of DPI (flavoprotein inhibitor) (A, B) and DHEA (G6PDH inhibitor) (C, D) on PER2::LUC rhythms. Left panels show traces of representative concentrations (mean ± SEM). Black arrows indicate change to drug-free media. Right panel shows dose-dependent effects of drug treatments (mean ± SEM, one-way ANOVA p-value for each parameter is reported). (E) DPI and DHEA do not reduce glycolytic flux (replicate numbers and Holm-Sidak p-values are reported). (F) Effect of oxythiamine (oxyth, transketolase inhibitor) on PER2::LUC rhythms (representative mean ± SEM). (G) Effect of oxythiamine treatment on PER2::LUC amplitude and period (one-way ANOVA p-value for each parameter is reported). *p < 0.05, ns, p > 0.05. DHEA, dehydroepiandrosterone; DPI, diphenyleneiodonium.