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. 2018 Mar 1;28(7):507–520. doi: 10.1089/ars.2016.6911

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© Marrit Putker, et al., 2018; Published by Mary Ann Liebert, Inc.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 6. — Redox balance regulates the amplitude of circadian rhythms in mouse fibroblasts. (A) Effect of chronic GOX and 2ME treatment on PER2::LUC rhythms, with treatment beginning at two opposite circadian phases (CT, CT0 or CT12) (representative mean ± SEM are shown [n = 4]). (B) Effect of 2ME and (C) GOX treatment on PER2::LUC amplitude and period (two-way ANOVA p-values for amplitude vs. concentration effect [n = 4]). 2ME, 2-mercaptoethanol; CT, circadian time; GOX, glucose oxidase.