Table 1.
Overview of Prx Subfamilies in Plants, Mammals, and Yeast
| Plant | Mammal | ||||||
|---|---|---|---|---|---|---|---|
| Type | Arabidopsis thaliana(1) | Oryza sativa(1) | Beta vulgaris(2) | Homo sapiens(1) | Mus musculus(1) | Rattus norvegicus(1) | Yeast Saccharomyces cerevisiae(1) |
| A | 2-CysPrxA (cl) Q96291 | 2-CysPrxA (cl) Q6ER94 | 2-CysPrx (cl) XM_010685313.1 | Prdx(ct) Q06830 | Prdx1(ct) P35700 | Prdx1(ct) Q63716 | Prx1, Tsa1 (ct) P34760 |
| 2-CysPrxB (cl) Q9C5R8 | — | — | Prdx2(ct) P32119 | Prdx2(ct) Q61171 | Prdx2(ct) P35704 | Prx2, Tsa2 (ct) Q04120 | |
| Prdx3(mt) P30048 | Prdx3(mt*) P20108 | Prdx3(mt*) Q9Z0 V6 | |||||
| Prdx4(ct) Q13162 | Prdx4(ct*) O08807 | Prdx4 (ct*) Q9Z0 V5 | |||||
| B | 1-CysPrx (ct, n) O04005 | 1-CysPrx (ct, n*) P0C5C9 | 1-CysPrx (ct, n) XM_010669313.1 | Prdx6(ct) P30041 | Prdx6(ct) O08709 | Prdx6(ct) O35244 | mTpx (mt) P34227 |
| C | PrxQ (cl) Q9LU86 | PrxQ (cl) P0C5D5 | PrxQ (cl) XM_010689254.1 | — | — | — | nTpx (n) P40553 |
| D | PrxIIA (—) Q7G959 | — | — | Prdx5(ct,mt,pr) P30044 | Prdx5 (ct,mt,pr) P99029 | Prdx5 (ct,mt,pr) Q9R063 | cTpx3 (ct) P38013 |
| PrxIIB (ct) Q9XEX2 | PrxIIB (ct) Q9FR35 | PrxIIB (ct) XM_010693075.1 | |||||
| PrxIIC (ct) Q9SRZ4 | — | — | |||||
| PrxIID (ct) O22711 | — | — | |||||
| PrxIIE (cl) Q949 U7 | PrxIIE1 (cl*) Q69TY4 | PrxIIE (cl) XM_010685588.1 | |||||
| PrxIIF (mt) Q9 M7T0 | PrxIIE2 (cl*) Q7F8S5 | — | |||||
| PrxIIF (mt*) Q9SDD6 | PrxIIF (mt) XM_010696978.1 | ||||||
Based on Hofmann et al. (49), Prxs were sorted with regard to their respective biochemical property of peroxidative cysteines and structure. In addition to the two plant model organisms, the newly sequenced genome of Beta vulgaris was included as additional example (51). For further information concerning subcellular localization, function, biochemical properties, and crystallographic data of annotated proteins, see the respective Uniprot entry (1) or reference sequence for B. vulgaris (2). Subcellular localization is given in parentheses as follows: nucleus = n, cytosol = ct, chloroplast = cl, mitochondria = mt, endoplasmatic reticulum = er, peroxisome = pr, not known = —. An * indicates manual assertion inferred from sequence similarity.