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. Author manuscript; available in PMC: 2019 Jan 8.
Published in final edited form as: Trends Cancer. 2018 Jan 8;4(1):10–19. doi: 10.1016/j.trecan.2017.11.007

Figure 2. Model for DISE.

Figure 2

A number of genes (donor (D) genes) in the human genome contain sequences that when transcribed into RNA are degraded/processed to generate small RNAs, by forming heteroduplexes within the same mRNA (in stem regions) or with other small RNA fragments, and are then loaded onto Ago proteins and the RISC. CD95L could be one of the D-genes. Such endogenous siRNAs and many si- and shRNAs designed to selectively silence genes target seed matches present in the 3′UTRs of survival genes (S genes) instead, resulting in the induction of DISE.