Table 3.

Variables Predicting Survival in UIP Cohort

	Unadjusted (n = 293)			Adjusted (n = 293)
Characteristic	HR	p-value	95% CI	HR	p-value	95% CI
ANA (+) a	1.46	0.02	1.07–1.98	1.59	0.007	1.13–2.23
NAC exposure	0.74	0.13	0.50–1.09	0.68	0.05	0.44–1.0
IPAF diagnosis b	1.11	0.52	0.80–1.57	0.99	0.97	0.67–1.48
Immunosuppressant exposure c	1.05	0.77	0.74–1.49	0.94	0.75	0.64–1.38
Anti-fibrotic exposure d	0.28	< 0.001	0.14-0.57	0.35	0.004	0.17–0.72
GAP Score	1.36	< 0.001	1.23–1.51	1.36	< 0.001	1.23–1.51

Abbreviations: IPF idiopathic pulmonary fibrosis, IPAF interstitial pneumonia with autoimmune features, UIP usual interstitial pneumonia, NAC N-acetylcysteine, ANA antinuclear antibody, GAP gender, age, physiology

^aANA titer ≥1:320 or nucleolar or centromere staining pattern at any titer

^bCompared to IPF diagnosis

^cPrednisone, azathioprine or mycophenolate

^dPirfenidone or nintedanib