Table 4.
Significant Relationships between peak cluster volumes and clinical parameters (Bcl-2 G-carriers)
| Seed region | EC | PCC | PCC | PCC | dLPFC |
|---|---|---|---|---|---|
| Peak cluster | Superior frontal | cerebellum | cerebellum | Sub-lobar | Superior frontal |
| Covariance strength relationship | G < AA | G > AA | G > AA | G < AA | G < AA |
| MNI coordinate | (12,14,57) | (-33,-57,-21) | (-23,-55,-20) | (-23,8,14) | (14,41,39) |
| Mini-mental state examination | 0.017 | 0.340 | 0.261 a | -0.171 | -0.227 a |
| T1 to T4 trial scores | -0.108 | 0.374 b | 0.291 a | -0.159 | -0.112 |
| 30 second recalls | -0.049 | 0.362 b | 0.193 | -0.104 | -0.112 |
| 10 minute recalls | -0.037 | 0.259 a | 0.197 | -0.087 | -0.192 |
| Modified Rey-Osterrieth Recall | -0.040 | 0.273 a | 0.177 | -0.056 | -0.118 |
| Modified Rey-Osterrieth Copy | -0.115 | 0.270 a | 0.181 | -0.020 | -0.090 |
| Visual object and Space Perception | -0.009 | 0.178 | -0.007 | -0.059 | -0.084 |
| Semantic fluency: Animal | -0.119 | 0.256 a | 0.161 | -0.083 | -0.206 |
| Boston Naming Test | 0.093 | 0.374 b | 0.214 | -0.073 | -0.144 |
| Comprehension | -0.045 | 0.317 b | 0.321 b | -0.420 b | -0.148 |
| Digit backward | 0.006 | 0.268 | 0.198 | -0.240 a | -0.112 |
| Stroop Interference Correct | -0.255 a | 0.234 | 0.152 | -0.085 | -0.118 |
| Design fluency | 0.058 | 0.228 | 0.049 | -0.015 | -0.113 |
| Trail making test time | 0.066 | -0.230 a | -0.076 | 0.201 | 0.194 |
| Correct line in Trail making | -0.139 | 0.286 a | 0.181 | -0.163 | -0.074 |
| Neuropsychiatric Inventory | -0.068 | -0.050 | -0.064 | -0.042 | 0.197 |
Numbers indicate Spearman correlation coefficient; ap < 0.05; b p <0.01; EC entorinal cortex, PCC posterior cingulate cortex, dLPFC dorsolateral prefrontal cortex