Table 4.
Univariate and multivariate analysis of risk factors associated with chronic rejection
| Univariate |
Multivariate |
|||
|---|---|---|---|---|
| Clinical characteristics | Odd ratio (95% CI) | p-value | Odd ratio (95% CI) | p-value |
| Recipient | ||||
| Age (years) | 1.08 (1.01–1.16) | 0.03 | 1.04 (0.99–1.09) | 0.09 |
| Male | 1.07 (0.13–8.63) | 0.95 | ||
| PRA HLA class I | 1.09 (0.96–1.03) | 0.93 | ||
| PRA HLA class II | 0.99 (0.97–1.02) | 0.78 | ||
| Positive cross-match | 0.74 (0.07–7.87) | 0.80 | ||
| Preformed DSA | 0.75 (0.07–7.63) | 0.81 | ||
| De novo DSA | 76.49 (8.83–97.55) | 0.0001 | 25.42 (7.72–89.73) | <0.0001 |
| Duration of TPN (mos) | 1.01 (0.99–1.02) | 0.22 | ||
| Number of surgery | 1.21 (0.71–1.98) | 0.75 | ||
| Rejection number ≤ 360 days | 3.21 (1.05–5.73) | 0.03 | 1.93 (1.46–2.57) | 0.04 |
| Donor | ||||
| Age (years) | 0.99 (0.91–1.08) | 0.88 | ||
| Male | 0.66 (0.19–2.26) | 0.51 | ||
| Cold-ischemic times, minutes | 1.47 (0.81–2.66) | 0.20 | ||
| Positive CMV | 5.87 (1.41–24.42) | 0.02 | 2.72 (1.68–13.24) | 0.003 |
| Liver allograft | 0.04 (0.00–0.53) | 0.014 | 0.21 (0.04–0.79) | 0.03 |
PRA, panel reactive antibody; HLA, human leukocyte antigen; DSA, donor-specific antibody; TPN, total parenteral nutrition; CMV, cytomegalovirus.