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. 2018 Jan 22;62(1):2873. doi: 10.4081/ejh.2018.2873

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©Copyright M. Boháè et al., 2018

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Figure 4. — Acellular dermal matrix before implantation. a) View of the decellularized skin at low magnification; Ep, remnants of epidermis; PD, papillary dermis; RD, reticular dermis. b) In the decellularized dermis, only collagen fibers are visible and no cells. c) Demonstration of the collagen fibers by Sirius red stain. d) Fragmentation of elastic fibers after the decellularization procedure (resorcin- fuchsin stain). e) Immunohistochemical identification of blood vessels. Inside the decellularized dermis, there are no CD34-positive cells. Diffuse and faint reactive staining for the CD34 antigen (probably from osmotically ruptured and removed cells) is present. f ) Inside the decellularized dermis, there are no detectable Factor VIII-positive endothelial cells. Only diffuse and faint reactive staining for the factor VIII antigen (probably from osmotically ruptured and removed cells) is present.