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. 2018 Jan 22;62(1):2873. doi: 10.4081/ejh.2018.2873

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©Copyright M. Boháè et al., 2018

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Figure 7. — Heterogeneous cell populations inside the implanted ADM. a) At the border between the ADM and host’s connective tissue, an accumulation of CD20-positive B-lymphocytes is observed; at the surface, synovial metaplastic cells form a pseudocapsule. b) The implanted ADM is housed by CD45RO-positive T-lymphocytes; T-lymphocytes are also present within the pseudocapsule formed by synovial metaplastic cells. c) At the border between the ADM and the host tissue, numerous macrophages (arrows) and occasion multinucleated giant cells (asterisk) are present (both are CD68-positive). d) The Naphthol AS-D Chloroacetate-Esterase reaction detects granulocytes inside the connective tissue of the ADM. e) Spindle-shaped, vimentin-positive cells (mostly fibroblasts, fibrocytes and blood endothelial cells) are observed. f ) Spindle-shaped cells positive for -smooth muscle actin (mostly myofibroblasts, pericytes and vascular smooth muscle cells) are observed.