Table IV.
TODAY participant (n = 521) end-of-study and overall* characteristics, T2D parameters, and echocardiography parameters by TNF-α group†
| (A) | (B) | (C) | ||
|---|---|---|---|---|
| TNF-αs (pg/mL) | Always normal (<5.6) (n = 352) | Intermittent (n = 127) | Always high (≥5.6) (n = 42) | P value |
| T2D duration (y) | 4.1 (1.4) | 4.0 (1.3) | 3.9 (1.4) | NS |
| Male (%) | 34.7% | 38.6% | 42.9% | NS |
| Race-ethnicity (%) | ||||
| Non-Hispanic black | 33.9% | 30.9% | 45.2% | NS |
| Hispanic | 44.5% | 49.6% | 38.1% | |
| Non-Hispanic white | 21.5% | 19.5% | 16.7% | |
| Treatment group (%) | ||||
| Metformin | 33.8% | 34.6% | 33.3% | NS |
| Metformin + rosiglitazone | 30.7% | 32.3% | 38.1% | |
| Metformin + lifestyle | 35.5% | 33.1% | 28.6% | |
| Failed to maintain glycemic control (%) | 46.6% | 48.8% | 47.6% | NS |
| End-of-study HbA1c (%) | 7.7 (2.5) | 7.7 (2.6) | 7.7 (2.2) | NS |
| Mean HbA1c during study (%) | 6.9 (1.5) | 6.9 (1.7) | 7.1 (1.6) | NS |
| End-of-study BMI (kg/m2) | 35.9 (8.7) | 37.4 (8.0) | 37.2 (6.4) | NS |
| Mean BMI during study (kg/m2) | 35.1 (8.0) | 36.4 (7.8) | 36.6 (6.5) | NS |
| End-of-study systolic BP (mm Hg) | 114.5 (11.1) | 116.3 (13.0) | 116.1 (10.0) | NS |
| Mean systolic BP during study (mm Hg) | 113.6 (9.3) | 115.9 (10.1) | 115.0 (8.0) | NS |
| End-of-study diastolic BP (mm Hg) | 69.0 (8.8) | 70.0 (9.4) | 69.3 (8.9) | NS |
| Mean diastolic BP during study (mm Hg) | 67.8 (6.7) | 68.9 (7.1) | 68.5 (5.5) | NS |
| LV mass (g) | 150.2 (44.9) | 161.2 (46.2) | 156.8 (38.6) | .0476 A vs B |
| LV mass/height2.7 (g/m2.7) | 36.9 (9.2) | 38.9 (8.5) | 38.7 (8.2) | NS |
| LV relative wall thickness | 0.34 (0.06) | 0.34 (0.06) | 0.34 (0.06) | NS |
| LV fractional shortening (%) | 38.5 (5.2) | 38.1 (5.2) | 37.5 (4.0) | NS |
| LA internal dimension (cm) | 3.57 (0.46) | 3.66 (0.46) | 3.54 (0.36) | NS |
| LA internal dimension/height (cm/m) | 2.13 (0.26) | 2.17 (0.26) | 2.12 (0.24) | NS |
| TAPSE (cm) | 2.15 (0.36) | 2.20 (0.38) | 2.07 (0.29) | NS |
| Doppler diastology | ||||
| LV E (cm/s) | 92.4 (18.3) | 92.7 (18.8) | 91.7 (19.7) | NS |
| LV Em (cm/s) | 16.8 (4.6) | 16.6 (4.2) | 17.1 (4.5) | NS |
| E/Em ratio | 5.8 (1.9) | 5.9 (1.7) | 5.6 (1.6) | NS |
*
Mean during the study.
†
All models adjusted for time in study (ie, similar to duration of diabetes). All echocardiography LV and Doppler diastology parameters are log transformed before testing due to skewed distributions. Pairwise comparisons are given for the significant associations found (P < .05).