Table 3.

Association between c-MYC amplification or polysomy for chromosome 8 and clinical response or disease status after completion of first-line treatment.

	Clinical response				Disease status
	No response	Responsea		p-value*	No evidence of disease	Positive for diseaseb		p-value*
c-MYC amplificationc
≥2 c-MYC/CEP8 copies
No	7 (18.4%)	31 (81.6%)	22 CR	1.000	14 (22.2%)	49 (77.8%)	34 + RL	1.000
			9 PR				15 + DP
Yes	3 (20.0%)	12 (80.0%)	5 CR		6 (24.0%)	19 (76.0%)	14 + RL
			7 PR				5 + DP
c-MYC amplificationd
≥ 1.5 c-MYC/CEP8 copies
No	3 (13.6%)	19 (86.4%)	15 CR	0.494	10 (28.6%)	25 (71.4%)	18 + RL	0.310
			4 PR				7 + DP
Yes	7 (22.6%)	24 (77.4%)	12 CR		10 (18.9%)	43 (81.1%)	30 + RL
			12 PR				13 + DP
Polysomy for chromosome 8e4 CEP8 copies
≥ 4 CEP8 copies
No	8 (23.5%)	26 (76.5%)	17 CR	0.299	15 (22.7%)	51 (77.3%)	37 + RL	1.000
			9 PR				14 + DP
Yes	2 (10.5%)	17 (89.5%)	10 CR		5 (22.7%)	17 (77.3%)	11 + RL
			7 PR				6 + DP

^aResponse includes a complete response (CR) or a partial response (PR).

^bPositive for disease includes those with microscopic or gross disease at reassessment laparotomy (+ RL) or with clinical evidence of disease progression documented during first-line treatment (+ DP).

^cc-MYC amplification was categorized as ‘No’ when tumors had <2 copies of c-MYC/CEP8 per cell or ‘Yes’ when tumors had ≥2 copies of c-MYC/CEP8 per cell.

^dc-MYC amplification was categorized as ‘No’ when tumors had <1.5 copies of c-MYC/CEP8 per cell or ‘Yes’ when tumors had ≥1.5 copies of c-MYC/CEP8 per cell.

^ePolysomy for chromosome 8 was categorized as ‘No’ when tumors had <4 copies of CEP8 per cell or ‘Yes’ when tumors had ≥4 copies of CEP8 per cell.

^*Fisher's Exact Test.