Table 3.
Associations between prediagnosis sleep duration and mortality among colorectal cancer patients in the NIH-AARP Diet and Health Study.
| Sleep duration | ||||
|---|---|---|---|---|
| <5 hr | 5–6 hr | 7–8 hr | 9+ hr | |
| All-cause death | ||||
| No. death | 84 | 710 | 1441 | 101 |
| HR (95% CI) | ||||
| Model 1 | 1.28 (1.03–1.60) | 0.98 (0.90–1.08) | ref | 0.99 (0.81–1.21) |
| Model 2 | 1.49 (1.18–1.89) | 0.98 (0.89–1.08) | ref | 1.10 (0.89–1.37) |
| Model 3 | 1.36 (1.08–1.72) | 0.96 (0.87–1.05) | ref | 1.08 (0.86–1.34) |
| Model 4 | 1.25 (0.98–1.58) | 0.94 (0.85–1.03) | ref | 1.04 (0.83–1.30) |
| Model 5 | 1.22 (0.96–1.56) | 0.93 (0.84–1.02) | ref | 1.02 (0.81–1.28) |
| Colorectal cancer death | ||||
| No. death | 45 | 368 | 782 | 55 |
| SHR (95% CI) | ||||
| Model 1 | 1.21 (0.89–1.64) | 0.93 (0.82–1.05) | ref | 0.98 (0.74–1.29) |
| Model 2 | 1.61 (1.15–2.25) | 0.95 (0.82–1.08) | ref | 1.08 (0.79–1.49) |
| Model 3 | 1.54 (1.11–2.14) | 0.93 (0.81–1.07) | ref | 1.07 (0.78–1.47) |
| Model 4 | 1.52 (1.10–2.11) | 0.93 (0.81–1.06) | ref | 1.08 (0.79–1.47) |
| Model 5 | 1.53 (1.10–2.12) | 0.93 (0.81–1.07) | ref | 1.08 (0.79–1.48) |
| Cardiovascular disease death | ||||
| No. death | 13 | 95 | 179 | 8 |
| SHR (95% CI) | ||||
| Model 1 | 1.60 (0.91–2.80) | 1.10 (0.85–1.41) | ref | 0.60 (0.29–1.22) |
| Model 2 | 1.56 (0.89–2.74) | 1.07 (0.83–1.37) | ref | 0.58 (0.28–1.18) |
| Model 3 | 1.41 (0.80–2.48) | 1.02 (0.79–1.31) | ref | 0.52 (0.26–1.07) |
| Model 4 | 1.23 (0.69–2.21) | 0.98 (0.76–1.27) | ref | 0.47 (0.23–0.96) |
| Model 5 | 1.19 (0.66–2.14) | 0.99 (0.76–1.28) | ref | 0.46 (0.23–0.95) |
Model 1: Adjusted for age at diagnosis (continuous) and sex (male, female).
Model 2: Adjusted for covariates in Model 1 and cancer site (colon, rectum), tumor stage (localized, regional), tumor grade (well differentiated, moderately differentiated, poorly differentiated, undifferentiated), surgery (yes, no), chemotherapy (yes, no), and radiation (yes, no).
Model 3: Adjusted for covariates in Model 2 and education (<12 years, high school, some college, college and post college), smoking (current, former, never smoker), TV viewing (≤2, 3–4, 5–6, 7+ hr/d), and MVPA (never or rarely, 1–3 hr/wk, 4+ hr/wk).
Model 4: Adjusted for covariates in Model 3, BMI (continuous), self-reported health (excellent, very good, good, fair, poor), and history (yes, no) of heart disease, stroke and diabetes.
Model 5: Adjusted for covariates in Model 4 and napping (none, <1 hr/d, 1+ hr/d).
Abbreviations: BMI, bodymass index; CI, confidence interval; HR, hazard ratio; hr, hour; MVPA, moderate-to-vigorous physical activity; SHR, subdistribution hazard ratio.