Table 4.
Associations between prediagnosis napping and mortality among colorectal cancer patients in the NIH-AARP Diet and Health Study.
| Napping | |||
|---|---|---|---|
| None | <1 hr | 1+ hr | |
| All-cause death | |||
| No. death | 940 | 1044 | 352 |
| HR (95% CI) | |||
| Model 1 | ref | 1.11 (1.01–1.21) | 1.44 (1.27–1.63) |
| Model 2 | ref | 1.13 (1.02–1.24) | 1.49 (1.31–1.69) |
| Model 3 | ref | 1.10 (1.00–1.21) | 1.35 (1.18–1.54) |
| Model 4 | ref | 1.05 (0.95–1.16) | 1.21 (1.05–1.39) |
| Model 5 | ref | 1.05 (0.96–1.16) | 1.21 (1.06–1.40) |
| Colorectal cancer death | |||
| No. death | 561 | 543 | 146 |
| SHR (95% CI) | |||
| Model 1 | ref | 0.98 (0.87–1.11) | 0.96 (0.80–1.15) |
| Model 2 | ref | 1.00 (0.87–1.14) | 0.98 (0.80–1.19) |
| Model 3 | ref | 1.00 (0.88–1.14) | 0.96 (0.78–1.18) |
| Model 4 | ref | 1.00 (0.87–1.14) | 0.95 (0.78–1.17) |
| Model 5 | ref | 1.00 (0.87–1.15) | 0.96 (0.78–1.18) |
| Cardiovascular disease death | |||
| No. death | 109 | 122 | 64 |
| SHR (95% CI) | |||
| Model 1 | ref | 1.03 (0.79–1.33) | 1.94 (1.42–2.66) |
| Model 2 | ref | 1.00 (0.77–1.31) | 1.98 (1.44–2.71) |
| Model 3 | ref | 0.95 (0.73–1.24) | 1.62 (1.18–2.24) |
| Model 4 | ref | 0.85 (0.65–1.12) | 1.28 (0.92–1.79) |
| Model 5 | ref | 0.84 (0.64–1.11) | 1.78 (0.91–1.78) |
Model 1: Adjusted for age at diagnosis (continuous) and sex (male, female).
Model 2: Adjusted for covariates in Model 1 and cancer site (colon, rectum), tumor stage (localized, regional), tumor grade (well differentiated, moderately differentiated, poorly differentiated, undifferentiated), surgery (yes, no), chemotherapy (yes, no), and radiation (yes, no).
Model 3: Adjusted for covariates in Model 2 and education (<12 years, high school, some college, college and post college), smoking (current, former, never smoker), TV viewing (≤2, 3–4, 5–6, 7+ hr/d), and MVPA (never or rarely, 1–3 hr/wk, 4+ hr/wk).
Model 4: Adjusted for covariates in Model 3, BMI (continuous), self-reported health (excellent, very good, good, fair, poor), and history (yes, no) of heart disease, stroke and diabetes.
Model 5: adjusted for covariates in Model 4 and napping (none, <1 hr/d, 1+ hr/d)
Abbreviations: BMI, bodymass index; CI, confidence interval; HR, hazard ratio; hr, hour; MVPA, moderate-to-vigorous physical activity; SHR, subdistribution hazard ratio.