Table 7.
Relationship Between Continuous Symptomless Multi-Variable Apnea Prediction and Postoperative Complications in Gender, BMI, and Age Strataa.
| Outcome | Gender stratification | ||||
|---|---|---|---|---|---|
| p interaction b | Female | Male | |||
| OR (95% CI)c | p d | OR (95% CI)c | p d | ||
| Extended length of stay | .433 | 1.11 (1.08, 1.13) | <.0001 | 1.10 (1.08, 1.13) | <.0001 |
| Any ICU-stay | .273 | 1.07 (1.05, 1.09) | <.0001 | 1.05 (1.04, 1.07) | <.0001 |
| Any respiratory complications | .745 | 1.08 (1.02, 1.14) | .005 | 1.09 (1.03, 1.15) | .002 |
| Outcome | BMI stratification | ||||
| p interaction b | BMI < 28.0 kg/m2 | BMI ≥ 28.0 kg/m2 | |||
| OR (95% CI)c | p d | OR (95% CI)c | p d | ||
| Extended length of stay | .003 | 1.27 (1.18, 1.37) | <.0001 | 1.14 (1.12, 1.16) | <.0001 |
| Any ICU-stay | <.0001 | 1.20 (1.13, 1.27) | <.0001 | 1.09 (1.08, 1.11) | <.0001 |
| Any respiratory complications | .186 | 1.19 (1.01, 1.40) | .038 | 1.13 (1.08, 1.19) | <.0001 |
| Outcome | Age stratification | ||||
| p interaction b | Age < 60.3 y | Age ≥ 60.3 y | |||
| OR (95% CI)c | p d | OR (95% CI)c | p d | ||
| Extended length of stay | .013 | 1.11 (1.09, 1.14) | <.0001 | 1.07 (1.04, 1.09) | <.0001 |
| Any ICU-stay | .701 | 1.05 (1.03, 1.07) | <.0001 | 1.03 (1.02, 1.05) | .0002 |
| Any respiratory complications | .076 | 1.12 (1.05, 1.20) | .001 | 1.03 (0.98, 1.08) | .256 |
| Outcome | BMI and age stratification | ||||
| p interaction b,e | BMI < 28.0 kg/m2 and age < 60.3 y | BMI ≥ 28.0 kg/m2 and age < 60.3 y | |||
| OR (95% CI)c | p d | OR (95% CI)c | p d | ||
| Extended length of stay | .388 | 1.21 (0.92, 1.60) | .173 | 1.13 (1.10, 1.17) | <.0001 |
| Any ICU-stay | .026 | 1.07 (0.89, 1.29) | .477 | 1.06 (1.04, 1.09) | <.0001 |
| Any respiratory complications | .203 | 1.72 (0.98, 3.30) | .102 | 1.16 (1.07, 1.25) | .0004 |
| BMI < 28.0 kg/m2 and age ≥ 60.3 y | BMI ≥ 28.0 kg/m2 and age ≥ 60.3 y | ||||
| OR (95% CI)c | p d | OR (95% CI)c | p d | ||
| Extended length of stay | 1.03 (0.94, 1.14) | .483 | 1.12 (1.09, 1.15) | <.0001 | |
| Any ICU-stay | 1.02 (0.95, 1.10) | .552 | 1.10 (1.07, 1.12) | <.0001 | |
| Any respiratory complications | 0.92 (0.75, 1.12) | .401 | 1.09 (1.01, 1.16) | .019 | |
BMI = Body mass index; CI = confidence interval; ICU = Intensive Care Unit; OR = Odds ratio; sMVAP = Symptomless Multi-Variable Apnea Prediction. Any ICU-stay defined as Any Stay in Intensive Care Unit. Any respiratory complications defined as diagnosis of Pulmonary Embolus, Acute Respiratory Distress Syndrome and/or Aspiration Pneumonia. Extended length of stay defined as a length of stay >90th percentile for given procedure code. Conditional regression model controlling for surgical category and hospital. Significant results shown in bold.
aAge and BMI stratification based on a median split in the analysis sample.
b p-value for interaction term (sMVAP × stratification variable).
cEstimates presented as OR and 95% CI, associated with a 0.1 unit increase in sMVAP.
d p-value from logistic regression model.
eFor combined BMI and Age stratification, pinteractione represents the p-value for sMVAP by 4-group interaction variable for each of the three outcomes.