Table 1.
Confirmed congenital anomaly cases among women with 4vHPV-exposed pregnancies, vaccinated August 2006 – March 2008.
| Case Number | Case Review Result | Timing of 4vHPV exposure | Number of 4vHPV doses during pregnancy | MACDP categorization |
|---|---|---|---|---|
| 1 | 1. Gastroschisis 2. Patent Ductus Arteriosus |
Second trimester | 1 | 1. Major 2. Minor |
| 2 | Anencephaly Note: Identified with genetics visit code (not live birth) |
Preconception | 1 | Major |
| 3 | Atrial septal defect | Preconception | 1 | Major |
| 4 | Atrial septal defect, ventricular septal defect | First trimester | 1 | Major |
| 5 | Branch pulmonary artery stenosis | Preconception | 1 | Major |
| 6 | Cerebral atrophy | Preconception | 1 | Major |
| 7 | Cleft lip / palate | First trimester | 1 | Major |
| 8 | Congenital hypoplasia depressor anguli oris muscle | Preconception | 1 | Major |
| 9 | Congenital knee dislocation | First trimester | 1 | Major |
| 10 | Congenital torticollis | First trimester | 1 | Major |
| 11 | Congenital torticollis | First trimester | 1 | Major |
| 12 | Down's syndrome | First trimester | 1 | Major |
| 13 | Glanular hypospadias | First trimester | 1 | Major |
| 14 | Hydronephrosis | Preconception | 1 | Major |
| 15 | Hydronephrosis | First trimester | 1 | Major |
| 16 | Hypospadias | First trimester | 1 | Major |
| 17 | Hypospadias / epispadias | Preconception | 1 | Major |
| 18 | Imperforate anus | Preconception | 1 | Major |
| 19 | Imperforate anus with rectovaginal fistula | First trimester | 1 | Major |
| 20 | Jejunal atresia | Preconception | 1 | Major |
| 21 | Plagiocephaly | First trimester | 1 | Major |
| 22 | Ptosis | First trimester | 1 | Major |
| 23 | Sacrococcygeal teratoma | First trimester | 1 | Major |
| 24 | Ventricular septal defect | First trimester; second trimester | 2 | Major |
| 25 | Ventricular septal defect | Preconception | 1 | Major |
| 26 | Accessory nipple | Second trimester | 1 | Minor |
| 27 | Hemangioma | First trimester | 1 | Minor |
| 28 | Lacrimal dacryostenosis | First trimester | 1 | Minor |
| 29 | Lacrimal dacryostenosis | First trimester | 1 | Minor |
| 30 | Lacrimal dacryostenosis | First trimester | 1 | Minor |
| 31 | Laryngomalacia | First trimester | 1 | Minor |
| 32 | Left preauricular skin tag | Preconception | 1 | Minor |
| 33 | Mongolian spots | Preconception | 1 | Minor |
| 34 | Patent ductus arteriosus | Preconception | 1 | Minor |
| 35 | Tongue tie | Preconception | 1 | Minor |
| 36 | Tongue tie | First trimester | 1 | Minor |
| 37 | Tongue tie | Preconception | 1 | Minor |
| 38 | Tongue tie | First trimester | 1 | Minor |
| 39 | Tongue tie | Preconception | 1 | Minor |
| 40 | Undescended testis | First trimester | 1 | Minor |
| 41 | Undescended testis | First trimester; second trimester | 2 | Minor |
| 42 | Undescended testis | Preconception | 1 | Minor |
| 43 | Undescended testis | Preconception | 1 | Minor |
| 44 | Undescended testis | First trimester | 1 | Minor |
MACDP = Metropolitan Atlanta Congenital Defects Program
*
Case 12 was vaccinated at 13th week of pregnancy and is classified as first trimester exposure (originally in the study, it was classified as second trimester exposure). For cases 24 and 41, both trimesters of vaccine exposure are shown here (originally in the study, only most recent trimester was counted).