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. 2018 Feb 5;150(2):225–244. doi: 10.1085/jgp.201711898

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© 2018 James and Zagotta

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 3. — Core architecture of CNBD channels. For clarity, the diagram omits the transmembrane regions (VSDs, pore domains) of the front and back subunits, along with the CNBD of the back subunit. The core domains of one subunit are highlighted, and include a VSD (gray), a pore domain (red), a C-linker domain (green), and a CNBD (blue). A cyclic nucleotide (cNMP, yellow) is also shown within CNBD binding pocket. All figures depicting protein structure were generated using the UCSF Chimera software package (Pettersen et al., 2004).