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. 2018 Feb 5;150(2):225–244. doi: 10.1085/jgp.201711898

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© 2018 James and Zagotta

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 6. — Selectivity filters of CNBD channels. (A) Stick representations of selectivity filters from the highly K⁺-selective rEAG1, hERG1, and LliK channels. Cation-binding sites 1–4, composed of backbone carbonyl groups and Ser(Thr) side chains, are labeled in the rEAG1 selectivity filter. (B) Stick representation of the weakly selective hHCN1 selectivity filter, with retained cation binding sites 3 and 4 labeled. (C) Stick representation of the nonselective TAX-4 selectivity filter, with highly conserved residue Glu379 labeled.