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. 2015 Dec 14;29(1):121–128. doi: 10.1177/0394632015600534

Table 3.

Susceptibilities of the Lactobacillus spp. to ampicillin, erythromycin, clindamycin, vancomycin, and gentamycin, in oral (I–V) and vaginal (VI–IX) products.

Product Taxon name obtained in this study Ampicillin
 Erythromycin
 Clindamycin
 Vancomycin
 Gentamycin
MIC mg/L Break point
 MIC mg/L Breakpoint
 MIC mg/L Breakpoint
 MIC mg/L Breakpoint
 MIC mg/L Breakpoint
CLSIa EFSAb CLSIa EFSAb CLSIa EFSAb CLSIa EFSAb CLSIa EFSAb
I L. rhamnosus ⩽0.25 S S ⩽0.25 S S ⩽0.25 S S >32 R NA >32 R R
II L. rhamnosus ⩽0.25 S S 0.5 S S 0.5 S S >32 R NA >32 R R
III L. paracasei ⩽0.25 S S ⩽0.25 S S ⩽0.25 S S >32 R NA >32 R R
IV L. reuteri ⩽0.25 S S ⩽0.25 S S ⩽0.25 S S >32 R NA >32 R R
V L. reuteri 1 S S ⩽0.25 S S ⩽0.25 S S >32 R NA >32 R R
VI L. plantarum ⩽0.25 S S ⩽0.25 S S ⩽0.25 S S >32 R NA >32 R R
VII L. plantarum ⩽0.25 S S ⩽0.25 S S ⩽0.25 S S >32 R NA >32 R R
VIII L. acidophilus - A 0.5 S S ⩽0.25 S S ⩽0.25 S S 1 S S >32 R R
L. acidophilus - B 0.5 S S ⩽0.25 S S ⩽0.25 S S 1 S S >32 R R
IX L. rhamnosus ⩽0.25 S S ⩽0.25 S S ⩽0.25 S S >32 R NA >32 R R
a

CLSI M45-P; Interpretative Criteria for Broth microdilution Susceptibility Testing:19 Ampicillin: Sensible ⩽8 mg/L; Erythromycin: Sensible ⩽0.5 mg/L, Intermediate 1–4 mg/L, Resistant ⩾8 mg/L; Clindamycin: Sensible ⩽0.5 mg/L, Intermediate 1–2 mg/L, Resistant ⩾4 mg/L; Vancomycin: Sensible ⩽4 mg/L, Intermediate 8–16 mg/L, Resistant ⩾32 mg/L; Gentamycin: Sensible ⩽4 mg/L, Intermediate 8 mg/L, Resistant ⩾16 mg/L.

b

EFSA Guidance on the assessment of bacterial antimicrobial susceptibility; microbiological cutoff values:20 Ampicillin: L. acidophilus group 1 mg/L, L. reuteri 2 mg/L, L. plantarum/pentosus 2 mg/L, L. rhamnosus 4 mg/L, L. casei/paracasei 4 mg/L; Erythromycin: L. acidophilus group 1 mg/L, L. reuteri 1 mg/L, L. plantarum/pentosus 1 mg/L, L. rhamnosus 1 mg/L, L. casei/paracasei 1 mg/L; Clindamycin: L. acidophilus group 1 mg/L, L. reuteri 1 mg/L, L. plantarum/pentosus 2 mg/L, L. rhamnosus 1 mg/L, L. casei/paracasei 1 mg/L; Vancomycin: L. acidophilus group 2 mg/L, L. reuteri n.r., L. plantarum/pentosus n.r., L. rhamnosus n.r., L. casei/paracasei n.r.; Gentamycin: L. acidophilus group 16 mg/L, L. reuteri 8 mg/L, L. plantarum/pentosus 16 mg/L, L. rhamnosus 16 mg/L, L. casei/paracasei 32 mg/L.