Infiltrated salivary glands of primary Sjögren’s syndrome patients, were classified according to serological markers. Patients were positive or negative for anti-SSA antibodies (Ab), anti-SSB Ab, rheumatoid factor (RF), and anti-centromere Ab (ACA). Grade differences between the positive and negative patients were: ***P <0.001 between SSB+ and SSB–, non-significant (NS) for SSA+ vs. SSA-, RF+ and RF–, and ACA+ vs. ACA– patients.