Table 1.
Demographical and general laboratory data and reference ranges of lymphocyte subsets (in total lymphocyte gate) for different age groups in healthy Turkish children.
| 0–1 year (n = 30) | 1–6 years (n = 30) | >6 years (n = 30) | P | |
|---|---|---|---|---|
| Age (months) | ||||
| Mean ± SD | 6.80 ± 3.57 | 42 ± 14.7 | 132.6 ± 50.3 | <0.001 |
| 2.5%–97.5%a | 1–12 | 16–72 | 76–282 | |
| Gender (n) | ||||
| Female | 9 | 15 | 10 | – |
| Male | 21 | 15 | 20 | |
| WBC (cells/mm3) | ||||
| Mean ± SD | 10,700 ± 3262 | 9851 ± 2772 | 7263 ± 2424 | <0.001 |
| 2.5%–97.5% | 3770–16,900 | 5460–18,300 | 3690–13,300 | |
| Absolute lymphocyte count (cells/mm3) | ||||
| Mean ± SD | 6156 ± 2046 | 4555 ± 1517 | 2779 ± 921 | <0.001 |
| 2.5%–97.5% | 2370–11,000 | 1050–9030 | 1340–5170 | |
| CD3+ T cells (cells/mm3) | ||||
| Mean ± SD | 4411 ± 1480 | 3220 ± 1180 | 1989 ± 709 | <0.001 |
| 2.5%–97.5%a | 1730–7680 | 506–7267 | 804–3837 | |
| CD3+ T cells (%) | ||||
| Mean ± SD | 71.5 ± 8.73 | 70.0 ± 7.18 | 71.6 ± 9.51 | 0.724 |
| 2.5%–97.5% | 54.2–92.9 | 48.2–81.4 | 48.6–89.4 | |
| CD19+ B cells (cells/mm3) | ||||
| Mean ± SD | 1179 ± 583 | 739 ± 329 | 377 ± 202 | <0.001 |
| 2.5%–97.5% | 63.9–2151 | 242–1459 | 89.1–1067 | |
| CD19+ B cells (%) | ||||
| Mean ± SD | 21.5 ± 6.68 | 16.5 ± 5.70 | 13.3 ± 4.78 | 0.001 |
| 2.5%–97.5% | 10.5–40.6 | 6.74–30.4 | 4.98–26.3 | |
| CD3+CD4+ T helper cells (cells/mm3) | ||||
| Mean ± SD | 2217 ± 845 | 1314 ± 542 | 818 ± 395 | <0.001 |
| 2.5%–97.5% | 630–3601 | 118–3245 | 202–1899 | |
| CD3+CD4+ T helper cells (%) | ||||
| Mean ± SD | 49.7 ± 8.54 | 40.3 ± 7.27 | 40.0 ± 10.1 | <0.001 |
| 2.5%–97.5% | 30.6–61.3 | 23.2–59.5 | 25–62.9 | |
| CD3+CD8+ T cytotoxic cells (cells/mm3) | ||||
| Mean ± SD | 902.6 ± 475 | 803 ± 417 | 515 ± 244 | 0.001 |
| 2.5%–97.5% | 276–2093 | 108–2367 | 212–1389 | |
| CD3+CD8+ T cytotoxic cells (%) | ||||
| Mean ± SD | 19.6 ± 5.89 | 24.2 ± 5.48 | 25.7 ± 5.58 | <0.001 |
| 2.5%–97.5% | 10.2–33.2 | 15.2–39 | 15.3–40.9 | |
| CD3-CD16+-56+ natural killer cells (cells/mm3) | ||||
| Mean ± SD | 344 ± 261 | 509 ± 295 | 264 ± 161 | 0.001 |
| 2.5%–97.5% | 74.0–1063 | 143–1599 | 50–721 | |
| CD3-CD16+-56+ Natural killer cells (%) | ||||
| Mean ± SD | 5.61 ± 3.07 | 11.2 ± 4.85 | 10.0 ± 5.63 | <0.001 |
| 2.5%–97.5% | 1.36–15.1 | 3.41–26.4 | 1.47–24.8 | |
| CD3+HLA-DR+ active T cells (cells/mm3) | ||||
| Mean ± SD | 388 ± 306 | 375 ± 235 | 241 ± 185 | 0.043 |
| 2.5%–97.5% | 92–1379 | 22–954 | 34–680 | |
| CD3+HLA-DR+ active T cells (%) | ||||
| Mean ± SD | 6.57 ± 5.50 | 7.84 ± 3.70 | 8.17 ± 5.0 | 0.408 |
| 2.5%–97.5% | 2.13–25.2 | 2.14–16.2 | 1.34–20.2 | |
WBC: white blood cells; SD: standard deviation.
a
Values represent percentile.