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. 2017 Oct 4;30(4):333–340. doi: 10.1177/0394632017734479

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — TLR-4 pathway mediators’ expression after eHSP60 stimulation, and IL-8 and CREB1 mRNA expression after p38 inhibition. p38α mRNA after (a) eHSP60 and (b) LPS stimulations; (c) p65 mRNA and (d) CREB1 mRNA after eHSP60 stimulation. p38α tended to increase at 2 h of treatment with eHSP60 (P = 0.0733); LPS up-regulated p38α at 1 h of exposure; eHSP60 exposure up-regulated p65 at 2 and 4 h of exposure as well as CREB1 at 4 h of exposure. (e) IL-8 and (f) CREB1 mRNA after a 30-min pre-treatment with the p38 inhibitor SB203580 (p38i) followed by treatment with eHSP60. The p38 inhibitor inhibited IL-8 mRNA up-regulation after 2 h (e) of exposure previously observed after the eHSP60 stimulation and abolished the CREB1 up-regulation after 4 h of exposure to eHSP60. Data are presented as mean ± SD of quadruplicate experiments.