Table 2.
Effects of gestational diabetes and CWP supplementation on the body weight and biochemical parameters of adult male offspring. The body weight at birth and at three months of age, blood parameters, and liver and kidney functions were measured in the offspring of the three groups of mice. The pooled data for 15 adult male offspring from each group are expressed as the mean value for each parameter ± SEM. * P < 0.05 for diabetic versus control; #P < 0.05 for diabetic + CWP versus control; +P < 0.05 for diabetic + CWP versus diabetic (ANOVA followed by Tukey’s post-test).
| Biochemical parameters | Offspring of control mothers | Offspring of diabetic mothers | Offspring of diabetic mothers administered CWP |
|---|---|---|---|
| Body weight (g) at birth | 1.23 ± 0.1 | 2.9 ± 0.36* | 1.29 ± 0.11† |
| At 3 months of age | |||
| Body weight (g) | 22 ± 2.6 | 27.4 ± 2.8* | 23.6 ± 2.9 |
| Blood glucose (mg/dl) | 153 ± 14.4 | 221 ± 21* | 189 ± 18†‡ |
| Insulin (ng/mL) | 11 ± 1.4 | 6.9 ± 1.1* | 9.98 ± 0.86† |
| WBC count (103/μL) | 14.2 ± 1.8 | 7.4 ± 0.8* | 11.8 ± 2.6† |
| Lymphocytes (%) | 75 ± 9.2 | 52 ± 6.2* | 71 ± 8.3†‡ |
| Monocytes (%) | 5 ± 0.6 | 4 ± 0.4 | 4 ± 0.7 |
| Neutrophils (%) | 19 ± 1.2 | 18 ± 0.88 | 18 ± 1.1 |
| Creatinine level (dg/mL) | 2.75 ± 0.3 | 2.8 ± 0.28 | 2.78 ± 0.39 |
| ALT activity (U/mL) | 50 ± 6.7 | 51 ± 6.1 | 49 ± 5.8 |
| AST activity (U/mL) | 47 ± 5.8 | 49 ± 6.5 | 45 ± 5.7 |
n = 15 male offspring/group.
P <0.05 for diabetic vs. control.
P <0.05 for diabetic + CWP vs. diabetic (ANOVA followed by Tukey’s post-test).
P <0.05 for diabetic + CWP vs. control.