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. 2018 Feb 9;13(2):e0192348. doi: 10.1371/journal.pone.0192348

Table 3. Upregulated genes in dorsal and ventral retina following a PT injury.

Fold changes comparing injured retina to region matched normal controls.

Gene Symbol GeneBank ID Dorsal retina / FC Injured/normal Ventral retina/ FC Injured/normal Function
Day 1 Day 7 Day 1 Day 7
Ecel1 NM_021776 16.20 * 11.80 * 2.10 Proteolysis
Timp1 NM_053819 4.60 * 3.30 * -2.25 * Metalloendopeptidase inhibitor activity
Mt2A NM_001137564 4.50 * 4.30 * Cellular zinc ion homeostasis
CD74 NM_013069 4.10 * 4.10 * Activation of MAPK activity
Gfap NM_017009 4.00 * 3.45 * -2.20 * Response to wounding (glia)
S100a11 NM_001004095 3.40 * 2.40* Calcium ion binding
Gpnmb NM_133298 3.40 * 2.80 * Cell adhesion
Tmem47 NM_001109317 3.30 * 2.40 * Cell-cell junction
Egr1 NM_012551 3.30 * 2.80 * Negative regulation of transcription from RNA polymerase II promoter
Arhgdib NM_001009600 3.20 * 2.50 * Rho GDP-dissociation inhibitor activity
H2afy2 NM_001135807 3.20 * 2.50 * Nucleosome assembly
Bgn NM_017087 3.10 * 2.40* Blood vessel remodelling
Tagln2 NM_001013127 3.00 * 2.70 * 1.50* Tumor suppressor
Dhdh XM_003748855 2.90 * D-xylose catabolic process
Sprr1a NM_021864 2.90 * 2.10 * Peptide cross-linking
Atf3 NM_012912 2.90 * 2.40* 1.50* Cell fate determination
Tmem108 XM_008757857 2.10* 2.20*
Rgr NM_001107299 2.30* 2.30* Retinal G-protein coupled receptor

Expression of significantly upregulated genes by fold change ≥ 2. Significance of p-value is indicated by *. Values that may not fall within those parameters are added for the purpose of comparison. Identified and known genes included in the table.