Table 4. Discriminant analysis on biological clusters related to oxidation-reduction, immune response and apoptosis after partial optic nerve injury.

		D1 PTD-NormD	D1 PTV-NormV	D7 PTD-NormD	D7 PTV-NormV	D7 PTD-D1 PTD	D7 PTV-D1 PTV	D1 PTV-D1 PTD	D7 PTV-D7 PTD
A	Oxidative stress
	Oxidation-reduction process	**	**	**	0.99	**	**	0.26	**
	Glutathione metabolic process	**	**	**	**	*	0.28	0.68	0.99
B	Immune response
	Adaptive immune response	**	**	**	**	**	0.09	0.51	0.82
	Innate immune response	**	**	**	**	0.51	0.48	**	**
	Cytokine-mediated signalling pathway	**	**	**	**	0.46	**	**	**
C	Apoptosis
	Apoptosis	**	**	**	**	**	**	**	**
	Extrinsic apoptotic pathway	**	**	**	**	**	**	**	**
	Intrinsic apoptotic pathway	**	**	**	**	**	**	**	**
	Intrinsic-response to ER stress	**	**	**	**	0.2	0.94	**	0.87
	Intrinsic-response to DNA damage	**	**	**	**	**	**	**	0.91
	Regulation of mitochondrial membrane permeability	*	**	**	**	0.2	0.58	*	0.99
	positive regulation of release of cytochrome c	0.76	**	**	**	**	**	**	**
	Response to ischemia	*	**	**	**	0.58	0.36	0.17	0.84

Discriminant analysis performed on biological clusters related to oxidation-reduction, immune response and apoptosis after partial optic nerve injury. Table illustrating the p-values of multiple comparisons of genes from dorsal and ventral retina from normal (norm) uninjured animals and at days 1 or 7 following PT injury associated with A: oxidation reduction (65 genes) and glutathione metabolic process (6 genes). B: Innate immune response (70 genes): adaptive immune response (32 genes); cytokine signalling pathway (30 genes). C) Apoptosis (81 genes): extrinsic apoptotic pathway (16 genes); intrinsic apoptotic pathway (18 genes); intrinsic apoptotic signalling pathway in response to ER (6 genes); intrinsic apoptotic signalling in response to DNA damage (10 genes); regulation of mitochondrial membrane permeability (7 genes); positive regulation of release of cytochrome c (6 genes); response to ischemia (5 genes). Comparisons were made between the dorsal and ventral retinal tissue of normal uninjured animals (NormD) and (NormV) respectively, dorsal and ventral retina at day 1 following PT (D1PTD) and (D1PT V) respectively and dorsal and ventral retina at day 7 following PT (D7PTD) and (D7PTV) respectively. P-values <0.001 are depicted by **, which P-values <0.05 are depicted by *. Non-significant differences are in grey.